CD197 (CCR7), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD197 (CCR7), Human
CloneREA108
Host SpeciesRecombinant Human
Reactive Specieshuman
IsotypeIgG1
Formatbiotin conjugate
Size30 tests in 60 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionCD197 (CCR7) Antibody, anti-human, Biotin, REAfinity™. REA108 recognizes human CD197 which is a chemokine receptor with a C-C motif that mediates homing of T cells to secondary lymphoid organs via high endothelial venules (HEV) and is also known as CCR7. For example, naive T cells migrate very efficiently through lymph nodes using the adhesion molecules L-selectin, CD62L, and CCR7. Ligands for CCR7, e.g. CCL19, are expressed by the HEV of secondary lymphoid organs, by parenchymal cells within T cell zones of lymph nodes, and by endothelial cells at the openings of lymphatic vessels within peripheral tissues. Expression of CCR7 and the CD45RA isoform distinguishes three subsets of T cells: naive T cells (CCR7+CD45RA+), central memory T cells (CCR7+ CD45RA-), and effector memory T cells (CCR7- CD45RA-). | Additional information: Clone REA108 displays negligible binding to Fc receptors. |
Immunogenn/a
Other NamesCCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1
Gene, Accession #Gene ID: 1236
Catalog #130-120-602
Price$92
Order / More InfoCD197 (CCR7), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesBacher, P. et al. (2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multi parameter characterization of specific conventional and regulatory CD4+ T cells. J Immunol 193: 3332-3343. | Sallusto, F. et al. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712. | Baldan, W. et al. (2015) Efficient and reproducible generation of tumour-infiltrating lymphocytes for renal cell carcinoma. Br. J. Cancer 112 (9): 1510-1518. | Frascaroli, G. et al. (2018) Human macrophages escape inhibition of major histocompatibility complex-dependent antigen presentation by Cytomegalovirus and drive proliferation and activation of memory CD4+ and CD8+ T cells. Front Immunol 9: . | Tilly, G. et al. (2017) IL-15 Harnesses Pro-inflammatory Function of TEMRA CD8 in Kidney-Transplant Recipients. Front Immunol 8: . | Alvarez-Fernandez, C. et al. (2016) A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy. J. Transl. Med. 14: 214. | Chang, Z. L. et al. (2015) Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J. Transl. Med. 13: 161.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

macs@miltenyibiotec.de

https://www.miltenyibiotec.com

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