TrkA, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TrkA, Human |
| Clone | REA430 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TrkA Antibody, anti-human, PE, REAfinity™. Clone REA430 recognizes the human TrkA antigen, a single-pass type I membrane protein which is also known as neurotrophic tyrosine kinase receptor type 1 (NTRK1). TrkA is a member of the neurotrophic tyrosine kinase receptor family and is involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation, and survival of sympathetic and nervous neurons. TrkA is the high affinity catalytic receptor for the nerve growth factor (NGF). As such, it mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death. Although originally isolated from neural tissues, a growing body of evidence supports a role for TrkA in tumorigenesis in non-neural tumors, primarily carcinomas. | Additional information: Clone REA430 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | NTRK1, MTC, TRK, TRK1, p140-TrkA, gp140trk |
| Gene, Accession # | Gene ID: 4914 |
| Catalog # | 130-117-705 |
| Price | $310 |
| Order / More Info | TrkA, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kiris, E. et al. (2014) TrkA in vivo function is negatively regulated by ubiquitination. J. Neurosci. 34 (11): 4090-4098. | Shelton, D. L. et al. (1995) Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J. Neurosci. 15 (1 Pt 2): 477-491. | Lagadec, C. et al. (2009) TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 28 (18): 1960-1970. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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