FoxP3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | FoxP3, Human |
| Clone | REA1253 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | FoxP3 Antibody, anti-human, APC, REAfinity™. Clone REA1253 recognizes the FoxP3 antigen, the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box P3, scurfin, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function. Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression. | Additional information: Clone REA1253 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | Gene ID: 50943 |
| Catalog # | 130-125-580 |
| Price | $325 |
| Order / More Info | FoxP3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Sakaguchi, S. et al. (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155: 1151-1164. | Hori, S. et al. (2003) Control of regulatory T cell development by the transcription factor FoxP3. Science 299: 1057-1061. | Walker, M. R. et al. (2003) Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J. Clin. Invest. 112: 1437-1443. | Jaeckel, E. et al. (2005) Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes 54: 306-310. | Gavin, M. A. et al. (2006) Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl. Acad. Sci. U.S.A. 103: 6659-6664. | Ziegler, S. F. (2006) FoxP3: of mice and men. Annu. Rev. Immunol. 24: 209-226. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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