IL-17A, human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityIL-17A, human
Host SpeciesRecombinant Human
Reactive Specieshuman
Formatallophycocyanin (APC) conjugate
Sizefor 30 tests
ApplicationsIntracellular flow cytometry
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionClone REA1063 recognizes human interleukin 17A (IL-17A). IL-17A, also known as CTLA8, is a member of the IL-17 family (IL-17A-F), is a disulfide-linked homodimeric glycoprotein. IL-17A is produced by CD4+ T helper (T?) cells, a third T cell subset termed T?17, which secrete also cytokines such as IL-17F and IL-22 and express the natural killer (NK) cell marker CD161. IL-17A secretion has also been described for other cell types, such as CD8+ memory T cells. Furthermore, intracellular IL-17A has also been detected in eosinophils, neutrophils, and blood monocytes. Emerging data about T?17 cells suggest that these cells are involved in the recruitment of neutrophils to control early stages of infections to a number of pathogens, such as extracellular bacteria and fungi. IL-17A and T?17 cells have been shown to play an important role in immune-mediated diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, asthma, inflammatory bowel diseases, and other immune-mediated inflammatory conditions. | Depending on the cytokine milieu present at time of the initial engagement, CD4+ naive T cells can differentiate into various subsets (T?1, T?2, and T?17). For the differentiation into T?17 cells several cytokines have been described, including TGF-β, IL-1β, IL-6, IL-21, and IL-23. RORγt was identified as the master regulator gene for T?17 cells. | Additional information: Clone REA1063 displays negligible binding to Fc receptors.
Other NamesCTLA-8, IL-17
Gene, Accession #Gene ID: 3605
Catalog #130-118-398
Order / More InfoIL-17A, human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesYao, Z. et al. (1995) Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155: 5483-5486. | Kolls, J. K. and Linden, A. (2004) Interleukin-17 family members and inflammation. Immunity 21: 467-476. | Ivanov, I. I. et al. (2006) The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133. | Cosmi, L. et al. (2008) Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J. Exp. Med. 205: 1903-1916. | Manel, H. et al. (2008) The differentiation of human T?-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat. Immunol. 9: 641-649. | Tesmer, L. A. et al. (2008) T?17 cells in human disease. Immunol. Rev. 223: 87-113. | Volpe, E. et al. (2008) A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human T?-17 responses. Nat. Immunol. 9: 650-657. | Yang, L. et al. (2008) IL-21 and TGF-beta are required for differentiation of human T?17 cells. Nature 454: 350-352.
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