Src pY418, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Src pY418, Human |
| Clone | REA434 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, rat, other |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Src pY418 Antibody, anti-human, PE, REAfinity™. Clone REA434 recognizes the human proto-oncogene tyrosine-protein kinase Src phosphorylated at tyrosine 418 (pY418). Src is a non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins, and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors, as well as cytokine receptors. It participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Src appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Src activity is regulated by phosphorylation at key sites, including the autophosphorylation site pY418 and the inhibitory site pY529. | Additional information: Clone REA434 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ASV, SRC1, c-Src, p60-Src, pp60c-src |
| Gene, Accession # | Gene ID: 6714 |
| Catalog # | 130-106-738 |
| Price | $110 |
| Order / More Info | Src pY418, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Roskoski, R. (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem. Biophys. Res. Commun. 331 (1): 1-14. | Wu, S. S. et al. (2005) Bombesin and angiotensin II rapidly stimulate Src phosphorylation at Tyr-418 in fibroblasts and intestinal epithelial cells through a PP2-insensitive pathway. Cell. Signal. 17 (1): 93-102. | Tanaka, A. et al. (1987) DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes. Mol. Cell. Biol. 7 (5): 1978-1983. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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