Aiolos, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityAiolos, Human
CloneREA881
Host SpeciesRecombinant
Reactive Specieshuman
IsotypeIgG1
Formatallophycocyanin (APC) conjugate
Size100 tests in 200 µL
Concentration1:50
ApplicationsIntracellular flow cytometry
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DescriptionAiolos Antibody, anti-human, APC, REAfinity™. Clone REA881 recognizes the human transcription factor aiolos, also known as IKZF3. Aiolos is a member of the ikaros family of zinc-finger proteins and forms heterodimers with other ikaros family members. It plays an essential role in the control of B lymphocyte differentiation and proliferation and in the regulation of BCL2 expression. Furthermore, it is involved in controlling apoptosis in T cells in an IL-2-dependent manner. Aiolos is found in peripheral blood leukocytes, spleen, and thymus. | Additional information: Clone REA881 displays negligible binding to Fc receptors.
Immunogenn/a
Other NamesIKZF3, Znfn1a3
Gene, Accession #Gene ID: 22806
Catalog #130-114-311
Priceplease inquire
Order / More InfoAiolos, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesRomero, F. et al. (1999) Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. EMBO J. 18 (12): 3419-3430. | Caballero, R. et al. (2007) Combinatorial effects of splice variants modulate function of Aiolos. J. Cell. Sci. 120 (15): 2619-2630. | Billot, K. et al. (2010) Differential aiolos expression in human hematopoietic subpopulations. Leuk. Res. 34 (3): 289-293.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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