Aiolos, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityAiolos, Mouse
CloneREA655
Host SpeciesRecombinant
Reactive Speciesmouse
IsotypeIgG1
Formatphycoerythrin (PE) conjugate
Size9 µg in 300 µL
Concentration1:10
ApplicationsIntracellular flow cytometry
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DescriptionAiolos Antibody, anti-mouse, PE, REAfinity™. Clone REA655 recognizes the mouse Aiolos antigen, a member of the Ikaros family of zinc finger transcription factors, also known as IKZF3. The expression is restricted to lymphoid tissues. Aiolos is highly expressed in spleen and mature B cells and at lower levels in thymus and bone marrow. It was first detected in more committed lymphoid progenitors and strongly up-regulated as these differentiate into pre-T and pre-B cell precursors. It is suggested, that the increase of Ikaros and Aiolos in differentiating lymphocytes is essential for normal progression to a mature and immunocompetent state. Aiolos interacts with Ikaros to regulate lymphocyte differentiation. | Additional information: Clone REA655 displays negligible binding to Fc receptors. |
Immunogenn/a
Other NamesIKZF3, Zfpn1a3, Znfn1a3, 5830411O07Rik
Gene, Accession #Gene ID: 22780
Catalog #130-110-341
Priceplease inquire
Order / More InfoAiolos, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesWang, J. H. et al. (1998) Aiolos regulates B cell activation and maturation to effector state. Immunity 9 (4): 543-553. | Morgan, B. et al. (1997) Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16 (8): 2004-2013. | Huttlin, E. L. et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143 (7): 1174-1189.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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