TIM-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TIM-1, Mouse |
| Clone | REA692 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIM-1 Antibody, anti-mouse, APC, REAfinity™. Clone REA692 recognizes the mouse T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein, also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by T?1, T?2, T?17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. TIM-1 expression has been demonstrated in epithelial cells, especially those of kidney origin, and is greatly increased in both mouse and human kidneys after injury. While absent on naive CD4 T cells, TIM-1 expression increases following TCR stimulation to provide positive co-stimulatory signal in T cell proliferation and T?1/T?17 cytokine production. It is reported, that the interaction of TIM-1 with TIM-4 is involved in the regulation of T cell proliferation. | Additional information: Clone REA692 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | HAVcr-1, TIMD-1, KIM-1, TIM, TIM1 |
| Gene, Accession # | Gene ID: 171283 |
| Catalog # | 130-110-326 |
| Price | $88 |
| Order / More Info | TIM-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Angiar, I. S. et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40 (4): 542-553. | Meyers, J. H. et al. (2005) TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol 6 (5): 455-464. | Feigelstock, D. et al. (1998) The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72 (8): 6621-6628. | Moller-Tank, S. et al. (2013) Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J. Virol. 87 (15): 8327-8341. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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