CD253, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD253, Human
CloneREA1113
Host SpeciesRecombinant Human
Reactive Specieshuman
IsotypeIgG1
FormatPE-Vio 615 conjugate
Size30 tests in 60 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionCD253 Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA1113 recognizes the human CD253 cytokine, a type II transmembrane protein also known as TNF-related apoptosis inducing ligand (TRAIL) or tumor necrosis factor ligand superfamily member 10 (TNFSF10), which induces the process of cell death. CD253 is predominantly found in spleen, lung, and prostate. It binds to the death receptors DR4 (TRAIL-RI) and DR5 (TRAIL-RII). CD253 can be expressed on transformed and virus infected cells. It can also be expressed on activated lymphocytes. | Additional information: Clone REA1113 displays negligible binding to Fc receptors.
Immunogenn/a
Other NamesTNFSF10, APO2L, Apo-2L, TL2, TRAIL
Gene, Accession #Gene ID: 8743
Catalog #130-119-386
Price$162
Order / More InfoCD253, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesWiley, S. R. et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3 (6): 673-682. | Pitti, R. M. et al. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271 (22): 12687-12690. | Almasan, A. et al. (2003) Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev. 14 (3-4): 337-348.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

macs@miltenyibiotec.de

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