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Antigenic Specificity | CD284, Human |
Clone | HTA125 |
Host Species | Mouse |
Reactive Species | human, other |
Isotype | IgG2aκ |
Format | biotin conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD284 Antibody, anti-human, Biotin. Clone HTA125 reacts with CD284, a type I transmembrane signaling receptor also known as Toll-like receptor 4 (TLR4). Toll-like receptors are a family of pattern recognition receptors detecting the presence and characteristics of an infection and induce appropriately tailored innate and adaptive immune responses. TLR4 associates with its co-receptor MD-2. Together with the lipopolysaccharide (LPS)-binding protein (LBP) and CD14, this complex is responsible for signaling upon LPS recognition. TLR4 is expressed on monocytes and myeloid dendritic cells. Low levels are expressed on B cells and granulocytes in human peripheral blood. HTA125 is able to block LPS-induced signaling and recognizes predominantly human TLR4 associated with MD-2. |
Immunogen | n/a |
Other Names | TLR4, ARMD10, TLR-4, TOLL |
Gene, Accession # | Gene ID: 7099 |
Catalog # | 130-097-349 |
Price | $264 |
Order / More Info | CD284, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Jin, M. S. and Lee, J-O. (2008) Structures of the toll-like receptor family and its ligand complexes. Immunity 29: 182-191. | Shimazu, R. et al. (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189: 1777-1782. | Burgener, I. et al. (2008) Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet. Immunol. Immunopathol. 124: 184-191. | Kawahara, T. et al. (2001) Type I Helicobacter pylori lipopolysaccharide stimulates Toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells. Infect. Immun. 69: 4382-4389. | Wang, J. et al. (2001) Involvement of CD14 and Toll-Like receptors in activation of human monocytes by Aspergillus fumigatus hyphae. Infect. Immun. 69: 2402-2406. | Wang, R. et al. (2003) Characterization of monoclonal antibody HTA125 with specificity for human TLR4. Hybrid. Hybridomics 22: 357-365. |