p120 Catenin pT310, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic Specificityp120 Catenin pT310, Human
CloneREA153
Host SpeciesRecombinant Human
Reactive Specieshuman, mouse, other
IsotypeIgG1
Formatphycoerythrin (PE) conjugate
Size30 tests in 300 µL
Concentration1:11
ApplicationsIntracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
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Descriptionp120 Catenin pT310 Antibody, anti-human, PE, REAfinity™. Clone REA153 recognizes the threonine residue (T310)-phosphorylated form of p120 Catenin, a prototypic member of subfamily of Armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1-7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Furthermore, lack of p120 Catenin in mouse leads to tumor development, suggesting its further role as tumor supressor. Phosphorylation of p120 Catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases. | Additional information: Clone REA153 displays negligible binding to Fc receptors.
Immunogenn/a
Other NamesCTNND1, CAS, CTNND, p120cas, p120ctn, p120, Catenin δ-1
Gene, Accession #Gene ID: 1500
Catalog #130-104-345
Price$110
Order / More Infop120 Catenin pT310, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesLiu, X. et al. (2014) Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility and metastasis. Cancer Res. 74 (5): 1609-1620. | Stairs, D. B. et al. (2011) Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell 19 (4): 470-483. | Reynolds, A. B. et al. (2004) Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene 23 (48): 7947-7956.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

macs@miltenyibiotec.de

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