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Antigenic Specificity | Stat3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 500 ug/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN alpha and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL 6, it has been shown that Stat3 beta appears to be activated by both while Stat3 alpha is activated by EGF, but not by IL 6. Highest expression of Stat4 is seen in testis and myeloid cells. IL 12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL 3. Stat6 is involved in IL 4 activated signaling pathways. |
Immunogen | Immunogen: Stat3 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 73 of rat Stat3 as the immunogen. |
Other Names | [Rabbit Stat3; Stat3; Stat3; Stat-3; Stat3; Stat 3; Stat-3; Stat 3; Stat-3] |
Gene, Accession # | [Stat3], Gene ID: 6774, NCBI: AAK17196.1 |
Catalog # | MBS5309118 |
Price | $705 |
Order / More Info | Stat3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |