PLC-gamma1 (Tyr-775), phospho-specific Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PLC-gamma1 (Tyr-775), phospho-specific |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody was cross-adsorbed to a non-specific phospho-tyrosine peptide then affinity-purified using phospho-PLC-gamma-1 (Tyr-775) peptide. The antibody detects a 150 kDa* protein in human Jurkat and A431 cells treated with pervanadate, but is not observed in untreated cells. Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors, and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLC-beta, PLC-gamma, PLC-delta, and PLC-epsilon. Phosphorylatio |
| Immunogen | Immunogen: PLC-gamma-1 (Tyr-775) synthetic peptide (coupled to carrier protein) corresponding to amino acids around tyrosine 775 in human PLC-gamma-1. This sequence has high homology to the conserved site in rat and mouse PLC-gamma-1, and has low homology to PLC-gamma-2. |
| Other Names | [PLCg1 (Tyr-775); phospho-specific; Phospholipase C gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1], [PLCG1; PLCG1; PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; PLC1] |
| Gene, Accession # | Gene ID: 5335, NCBI: NP_002651.2, UniProt: P19174 |
| Catalog # | MBS472053 |
| Price | $385 |
| Order / More Info | PLC-gamma1 (Tyr-775), phospho-specific Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Obermeier, A. et al. (1996) EMBO J. 15:73.• Chen, P. et al. (1996) J Cell. Biol. 134:689.• Serrano, C.J. et al. (2005) J. Immunol. 174:6233. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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