Edit |   |
---|---|
Antigenic Specificity | MCL-1 |
Clone | [8C6; 8C6D4B1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Entrez Summary: Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysa |
Immunogen | Immunogen: Purified recombinant fragment of human MCL-1 expressed in E Coli. |
Other Names | [EAT; MCL1L; MCL1S], [EAT, MCL1L, MCL1S] |
Gene, Accession # | [MCL-1], Gene ID: 4170, NCBI: AAF64255.1 |
Catalog # | MBS475660 |
Price | $335 |
Order / More Info | MCL-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |