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Antigenic Specificity | M6PR |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. |
Immunogen | Immunogen: A synthesized peptide derived from human M6PR. Subcellular Localization: Lysosome membrane; Single-pass type I membrane protein. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface. |
Other Names | [Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222; IGF2R; MPRI], [IGF2R] |
Gene, Accession # | [M6PR], Gene ID: 3482, NCBI: NP_000867.2, UniProt: P11717 |
Catalog # | MBS179498 |
Price | $160, $340, $340 |
Order / More Info | M6PR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |