Phospho-PI3K p85 alpha (Tyr607) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-PI3K p85 alpha (Tyr607)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat, porcine
Isotypen/a
Formatpeptide affinity purified
Size0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
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DescriptionSpecificity: Phospho-PI3-kinase p85-alpha (Tyr607) antibody detects endogenous levels of PI3-kinase p85-alpha only when phosphorylated at Tyrosine 607. Description: PIK3R1 is a regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR
ImmunogenImmunogen: A synthesized peptide derived from human PI3-kinase p85-alpha around the phosphorylation site of Tyrosine 607 Subcellular Location: Cytoplasmic Tissue Specificity: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level). Predicted Cross Reactivity: Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%
Other Names[GRB 1; GRB1; p85 alpha; p85; P85A_HUMAN; Phosphatidylinositol 3 kinase associated p 85 alpha; Phosphatidylinositol 3 kinase regulatory 1; Phosphatidylinositol 3 kinase regulatory subunit alpha; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 1 (p85 alpha); Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphoinositide 3 kinase regulatory subunit 1 (alpha); Phosphoinositide 3 kinase regulatory subunit 1 (p85 alpha); Phosphoinositide 3 kinase regulatory subunit 1; Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha); PI3 kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K; PI3K regulatory subunit alpha; Pik3r1; PtdIns 3 kinase p85 alpha; PtdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-alpha]
Gene, Accession #[PIK3R1], Gene ID: 5295, NCBI: NP_001229395.1, UniProt: P27986
Catalog #MBS9601012
Price$240, $280
Order / More InfoPhospho-PI3K p85 alpha (Tyr607) Antibody from MYBIOSOURCE INC.
Product Specific ReferencesChang M, Guo F, Zhou Z, Huang X, Yi L, Dou Y, Huan J; Journal: Cell Signal. HBP induces the expression of monocyte chemoattractant protein-1 via the FAK/PI3K/AKT and p38 MAPK/NF-kB pathways in vascular endothelial cells. Shang L, Wang T, Tong D, Kang W, Liang Q, Ge S; Journal: Cell Prolif. Prolyl hydroxylases positively regulated LPS-induced inflammation in human gingival fibroblasts via TLR4/MyD88-mediated AKT/NF-kB and MAPK pathways. Liu Y, Geng L, Zhang J, Wang J, Zhang Q, Duan D, Zhang Q; Journal: Mar Drugs. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway. Chai L, Bai L, Li L, Chen F, Zhang J; Journal: Exp Ther Med. Biological functions of lung cancer cells are suppressed in co-culture with mesenchymal stem cells isolated from umbilical cord. Wang W, Li L, Chen F, Yang Y; Journal: Oncol Rep. Umbilical cord-derived mesenchymal stem cells can inhibit the biological functions of melanoma A375 cells.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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