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Antigenic Specificity | MHC Class II (I-A) |
Clone | [NYRmI-A] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG2a |
Format | ion exchange purified |
Size | 0.5 mg, 1 mg |
Concentration | 1mg/ml in PBS (after reconstitution). |
Applications | n/a |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes most MHC class II haplotypes (b,f,p,q,r,s,u,v), but weak against I-Ak. Introduction: MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the invariant chain, is necessary for stabili |
Immunogen | Immunogen: Purified mouse LN B cells (C3H anti-C57Bl6). Antibody Properties: Cytotoxic and staining antibody. For staining, use 10ml/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator. Available Conjugates: This antibody is also available conjugated to biotin and FITC. |
Other Names | [MHC Class II, I-A; MHC Class II, (I-A) Mouse], [HLA-DQB1] |
Gene, Accession # | [MHC Class II], NCBI: O19707 |
Catalog # | MBS140116 |
Price | $305, $455 |
Order / More Info | MHC Class II (I-A) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |