INDO Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityINDO
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionINDO/IDO1/indoleamine 2, 3-dioxygenase (IDO) is an IFN-gamma-inducible enzyme that catalyzes the rate-limiting step of tryptophan degradation (1). IDO is upregulated in many tumors and in dendritic cells in tumor-draining lymph nodes. Elevated tryptophan catabolism in these cells leads to tryptophan starvation of T cells, limiting T cell proliferation and activation (2). Therefore, IDO is considered an immunosuppresive molecule, and research studies have shown that upregulation of IDO is a mechanism of cancer immune evasion (3). The gastrointestinal stromal tumor drug, imatinib, was found to act, in part, by reducing IDO expression, resulting in increased CD8+ T cell activation and induction of apoptosis in regulatory T cells (4). In additi
ImmunogenImmunogen: Recombinant protein of human INDO Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[CD107B; IDO; INDO]
Gene, Accession #[INDO], Gene ID: 3620, NCBI: NP_002155.1, UniProt: P14902
Catalog #MBS8502362
Price$280
Order / More InfoINDO Antibody from MYBIOSOURCE INC.
Product Specific References1. Yasui, H. et al. (1986) Proc Natl Acad Sci U S A 83, 6622-6. 2. Mellor, A.L. et al. (2003) Adv Exp Med Biol 527, 27-35. 3. Prendergast, G.C. (2008) Oncogene 27, 3889-900. 4. Balachandran, V.P. et al. (2011) Nat Med 17, 1094-100. 5. Pallotta, M.T. et al. (2011) Nat Immunol 12, 870-8.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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