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Antigenic Specificity | INDO |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | INDO/IDO1/indoleamine 2, 3-dioxygenase (IDO) is an IFN-gamma-inducible enzyme that catalyzes the rate-limiting step of tryptophan degradation (1). IDO is upregulated in many tumors and in dendritic cells in tumor-draining lymph nodes. Elevated tryptophan catabolism in these cells leads to tryptophan starvation of T cells, limiting T cell proliferation and activation (2). Therefore, IDO is considered an immunosuppresive molecule, and research studies have shown that upregulation of IDO is a mechanism of cancer immune evasion (3). The gastrointestinal stromal tumor drug, imatinib, was found to act, in part, by reducing IDO expression, resulting in increased CD8+ T cell activation and induction of apoptosis in regulatory T cells (4). In additi |
Immunogen | Immunogen: Recombinant protein of human INDO Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [CD107B; IDO; INDO] |
Gene, Accession # | [INDO], Gene ID: 3620, NCBI: NP_002155.1, UniProt: P14902 |
Catalog # | MBS8502362 |
Price | $280 |
Order / More Info | INDO Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Yasui, H. et al. (1986) Proc Natl Acad Sci U S A 83, 6622-6. 2. Mellor, A.L. et al. (2003) Adv Exp Med Biol 527, 27-35. 3. Prendergast, G.C. (2008) Oncogene 27, 3889-900. 4. Balachandran, V.P. et al. (2011) Nat Med 17, 1094-100. 5. Pallotta, M.T. et al. (2011) Nat Immunol 12, 870-8. |