IKB alpha Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | IKB alpha |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for NF-kappa-B inhibitor alpha(NFKBIA) detection. Tested with WB, IHC-P in Human;Mouse;Rat. Background: NFKBIA, also called IKBA or MAD-3, is one member of a family of cellular proteins that function to inhibit the NF-kappaB transcription factor. It is mapped to 14q13.2. NFKBIA inhibits NF-kappaB by masking the nuclear localization signals(NLS) of NF-kappaB proteins and keeping them sequestered in an inactive state in the cytoplasm. It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. The effect of the nonpathogenic bacteria is specific to the SCF complex substrates CTNNB1 and NFKBIA. This may help to explain the beneficial effects of t |
| Immunogen | Immunogen: E Coli-derived human IKB alpha recombinant protein (Position: Q3-Q112). Human IKB alpha shares 87% and 86% amino acid (aa) sequence identity with mouse and rat IKB alpha, respectively. Ig Type: Rabbit IgG |
| Other Names | [NF-kappa-B inhibitor alpha; I kappa B alpha; I(Kappa)B(alpha); I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA_HUMAN; IKBalpha; MAD 3; MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappa-B inhibitor alpha; NFKBI; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha], [NFKBIA; NFKBIA; IKBA; MAD-3; NFKBI; IKBA; MAD3; NFKBI; IkB-alpha; IkappaBalpha] |
| Gene, Accession # | [IKB alpha], Gene ID: 4792, NCBI: NP_065390.1, UniProt: P25963 |
| Catalog # | MBS178205 |
| Price | $315 |
| Order / More Info | IKB alpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Jacobs MD, Harrison SC (1998). Structure of an IkappaBalpha/NF-kappaB complex. Cell 95 (6): 749-58. 2. Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., Madara, J. L. Prokaryotic regulation of epithelial responses by inhibition of I-kappa-B-alpha ubiquitination. Science 289: 1560-1563, 2000. 3. Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S (1995). Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev.9 (22): 2723-35. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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