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Antigenic Specificity | CD257/BAFF/TNFSF13B |
Clone | [C257/1638] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA at 1mg/ml) |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: BAFF/CD257 is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. It is proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homo-trimers. The predicted molecular weight of a BAFF monomer is approximately 31kDa. It is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN-gamma and down-regulated by PMA/ionomycin treatment. BAFF stimulates B and T cell immunity and regulates humoral immunity by binding TACI and BCMA receptors; BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3). |
Immunogen | Immunogen: Purified recombinant human full-length CD257 protein. Cellular Localization: Cell Surface and Cytoplasmic |
Other Names | [ApoL related ligand TALL 1; B lymphocyte stimulator; B-cell-activating factor; BAFF; BLyS; CD257; Dendritic cell-derived TNF-like molecule; DTL; PRO738; TALL-1; THANK; TNFSF13B; TNFSF20; Tumor necrosis factor ligand superfamily member 13b; Tumor necrosis factor ligand superfamily member 20; ZTNF4], [BAFF; TNFSF13B] |
Gene, Accession # | [CD257], Gene ID: 10673, NCBI: NP_001139117.1, UniProt: Q9Y275 |
Catalog # | MBS439850 |
Price | $190, $340, $340 |
Order / More Info | CD257/BAFF/TNFSF13B Antibody from MYBIOSOURCE INC. |
Product Specific References | Schneider P, et al. 1999. J. Exp. Med. 189:1747. Moore PA, et al. 1999. Science 285:260. |