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Antigenic Specificity | LDLR |
Clone | [2D9A12] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. |
Immunogen | Immunogen: Purified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli. |
Other Names | [FH; FHC; LDLCQ2] |
Gene, Accession # | [LDLR], Gene ID: 3949, NCBI: NP_000518.1, UniProt: P01130 |
Catalog # | MBS8539475 |
Price | $280 |
Order / More Info | LDLR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |