LDLR Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityLDLR
Clone[2D9A12]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA)
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DescriptionThe low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
ImmunogenImmunogen: Purified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli.
Other Names[FH; FHC; LDLCQ2]
Gene, Accession #[LDLR], Gene ID: 3949, NCBI: NP_000518.1, UniProt: P01130
Catalog #MBS8539475
Price$280
Order / More InfoLDLR Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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