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Antigenic Specificity | IGF1R-beta |
Clone | [3C8B1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Entrez Summary: IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function, including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine au |
Immunogen | Immunogen: Purified recombinant fragment of IGF1R-Beta expressed in E Coli. |
Other Names | [IGF1R; IGF1R-Beta], [IGF1R, IGF1R-Beta] |
Gene, Accession # | [IGF1R-beta], Gene ID: 3480 |
Catalog # | MBS475747 |
Price | $335 |
Order / More Info | IGF1R-beta Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |