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Antigenic Specificity | PERK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | PERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2alpha kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2alpha to promote reduced translation. PERK-deficient mice have defects in pancreatic beta cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status. |
Immunogen | Immunogen: A synthetic peptide of human PERK Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [EIF2AK3; DKFZp781H1925; HRI; PEK; PERK; WRS] |
Gene, Accession # | [PERK], Gene ID: 9451, NCBI: NP_004827.4, UniProt: Q9NZJ5 |
Catalog # | MBS8503006 |
Price | $310 |
Order / More Info | PERK Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Harding, H. et al. (1999) Nature 397, 271-274. 2. Shi, Y. et al. (1998) Mol. Cell. Biol. 18, 7499-7509. 3. Harding, H. et al. (2000) Mol. Cell 5, 897-904. 4. Harding, H. et al. (2001) Mol. Cell 7, 1153-1163. |