PERK Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPERK
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB)
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DescriptionPERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2alpha kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2alpha to promote reduced translation. PERK-deficient mice have defects in pancreatic beta cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status.
ImmunogenImmunogen: A synthetic peptide of human PERK Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[EIF2AK3; DKFZp781H1925; HRI; PEK; PERK; WRS]
Gene, Accession #[PERK], Gene ID: 9451, NCBI: NP_004827.4, UniProt: Q9NZJ5
Catalog #MBS8503006
Price$310
Order / More InfoPERK Antibody from MYBIOSOURCE INC.
Product Specific References1. Harding, H. et al. (1999) Nature 397, 271-274. 2. Shi, Y. et al. (1998) Mol. Cell. Biol. 18, 7499-7509. 3. Harding, H. et al. (2000) Mol. Cell 5, 897-904. 4. Harding, H. et al. (2001) Mol. Cell 7, 1153-1163.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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