Phospho-Histone H2A.x-S139 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-Histone H2A.x-S139
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size0.05 mL, 0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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DescriptionHistone H2A.X is a variant histone that represents approximately 10% of the total H2A histone proteins in normal human fibroblasts (1). H2A.X is required for checkpoint-mediated cell cycle arrest and DNA repair following double-stranded DNA breaks (1). DNA damage, caused by ionizing radiation, UV-light, or radiomimetic agents, results in rapid phosphorylation of H2A.X at Ser139 by PI3K-like kinases, including ATM, ATR, and DNA-PK (2,3). Within minutes following DNA damage, H2A.X is phosphorylated at Ser139 at sites of DNA damage (4). This very early event in the DNA-damage response is required for recruitment of a multitude of DNA-damage response proteins, including MDC1, NBS1, RAD50, MRE11, 53BP1, and BRCA1 (1). In addition to its role in
ImmunogenImmunogen: A phospho specific peptide corresponding to residues surrounding S139 of human Histone H2A.x Calculated Molecular Weight: 14kDa
Other Names[Phospho-H2AFX-S139: H2AFX; Histone H2A.x], [H2AFX; H2AFX; H2AX; H2A.X; H2A/X; H2AX; H2a/x]
Gene, Accession #[H2AFX], Gene ID: 3014, NCBI: P16104.2, UniProt: P16104
Catalog #MBS126189
Price$235, $350, $525
Order / More InfoPhospho-Histone H2A.x-S139 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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