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Antigenic Specificity | ZO1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Tight junctions, or zona occludens, form a continuous barrier to fluids across the epithelium and endothelium. They function in regulation of paracellular permeability and in the maintenance of cell polarity, blocking the movement of transmembrane proteins between the apical and the basolateral cell surfaces (reviewed in 1). Zona occludens proteins ZO-1, -2, and -3 (also known as TJP1, 2, and 3) are peripheral membrane adaptor proteins that link junctional transmembrane proteins such as occludin and claudin to the actin cytoskeleton (reviewed in 2). ZO-1 and -2 are required for tight junction formation and function (3,4). In subconfluent proliferating cells, ZO-1 and ZO-2 have been shown to colocalize to the nucleus and play a role in trans |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [TJP1; DKFZp686M05161; MGC133289; ZO-1], [TJP1; TJP1; ZO-1; ZO1] |
Gene, Accession # | [TJP1], Gene ID: 7082, NCBI: Q07157.3, UniProt: Q07157 |
Catalog # | MBS125603 |
Price | $200, $275, $430 |
Order / More Info | ZO1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |