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Antigenic Specificity | GluA1/GluR1 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunoblot (IB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes mouse and rat GluA1/GluR1. It does not cross-react with GluR2. Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) plays a key role in altering excitatory synaptic transmission in the CNS. Interestingly, the regulatory mechanisms differ between distinct subunits of AMPAR, which range from glutamate receptor 1 (GluR1) to GluR4 (also referred to as GluA1-4). For example, subunits with a long intracellular carboxy terminus (i.e., GluR1, GluR2L, and GluR4) are involved in activity-dependent synaptic targeting of AMPAR, whereas those with a shorter carboxy terminus (i.e., GluR2, GluR3, and GluR4s) seem to maintain basal synaptic transmission. GluR1 has several phosphorylation sites |
Immunogen | Antigen: Fusion protein corresponding to aa 1-389 (extracellular N-terminus) of rat GluA1/GluR1 (accession no. P19490). |
Other Names | [GluA1/GluR1], [GRIA1; GRIA1; GLUH1; GLUR1; GLURA; GluA1; HBGR1; GLUH1; GLUR1; GluR-1; GluA1] |
Gene, Accession # | [GluA1/GluR1], Gene ID: 2890, NCBI: NP_000818.2 |
Catalog # | MBS190931 |
Price | $410 |
Order / More Info | GluA1/GluR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |