Transferrin receptor 1, Human Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityTransferrin receptor 1, Human
Clone3B8 2A1
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1
Formatunconjugated
Size0.1 mg
Concentrationn/a
ApplicationsF, Flow Cytometry (FC/FACS), Immunoassay (IA), Immunoprecipitation (IP), Western Blot (WB)
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DescriptionProduct Description: Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2.
Immunogenn/a
Other Names[transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor 1], [TFRC]
Gene, Accession #Gene ID: 711568, NCBI: NP_001244232.1
Catalog #MBS584010
Price$420
Order / More InfoTransferrin receptor 1, Human Antibody from MYBIOSOURCE INC.
Product Specific References1. Vogt, T et al; Heterotypic interactions between transferrin receptor and transferrin receptor 2. Blood 2003, 101: 2008 2. Johnson, M et al; Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 2004, 104: 4287
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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