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Antigenic Specificity | Transferrin receptor 1, Human |
Clone | 3B8 2A1 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | F, Flow Cytometry (FC/FACS), Immunoassay (IA), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45% identity with TfR2. |
Immunogen | n/a |
Other Names | [transferrin receptor protein 1; transferrin receptor protein 1; transferrin receptor 1], [TFRC] |
Gene, Accession # | Gene ID: 711568, NCBI: NP_001244232.1 |
Catalog # | MBS584010 |
Price | $420 |
Order / More Info | Transferrin receptor 1, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Vogt, T et al; Heterotypic interactions between transferrin receptor and transferrin receptor 2. Blood 2003, 101: 2008 2. Johnson, M et al; Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 2004, 104: 4287 |