Phospho-EIF4EBP1-S65 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-EIF4EBP1-S65
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.05 mL, 0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB)
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DescriptionTranslation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2,3). Multiple 4E-BP1 residues are phosphorylated in vivo (4). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5).
ImmunogenImmunogen: A phospho specific peptide corresponding to residues surrounding S65 of human EIF4EBP1
Other Names[Phospho-EIF4EBP1-S65: 4E-BP1; 4EBP1; BP-1; MGC4316; PHAS-I], [EIF4EBP1; EIF4EBP1; BP-1; 4EBP1; 4E-BP1; PHAS-I; 4E-BP1; eIF4E-binding protein 1; PHAS-I]
Gene, Accession #[EIF4EBP1], Gene ID: 1978, NCBI: Q13541.3, UniProt: Q13541
Catalog #MBS125564
Price$235, $350, $525
Order / More InfoPhospho-EIF4EBP1-S65 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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