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Antigenic Specificity | TLR4, Human |
Clone | 3C3 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), FS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody 3C3 reacts with human Toll-like receptor 4 (TLR4, CD284). TLRs belong to a family of proteins that specifically recognize and sense microbial products. They are highly conserved throughout evolution. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. TLRs identified as type I transmembrane signalling receptors act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. TLR4 has been identified next to MD-2 and CD14 as a receptor that is ce |
Immunogen | Immunogen: CHO cells expressing chimeric human TLR4/MD-2 fusion protein |
Other Names | [TLR4, partial; TLR4; TLR4; Toll-like receptor 4], [TLR4] |
Gene, Accession # | [TLR4], NCBI: ACX37356.1 |
Catalog # | MBS584003 |
Price | $470 |
Order / More Info | TLR4, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |