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Antigenic Specificity | Lrp2/Megalin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Lrp2/Megalin antibody detects endogenous levels of total Lrp2/Megalin. Function: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endoc |
Immunogen | Immunogen: A synthesized peptide derived from human Lrp2/Megalin Subcellular Location: Membrane. Membrane > Coated Pit. Tissue Specificity: Expressed in first and third trimester cytotrophoblasts in the placenta (at protein level) (PubMed:27798286). Absorptive epithelia, including renal proximal tubules. Predicted Cross Reactivity: Horse Similarity: Horse (89%) |
Other Names | [Calcium sensor protein; DBS; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; Low-density lipoprotein receptor-related protein 2; LRP-2; Lrp2; LRP2_HUMAN; Megalin] |
Gene, Accession # | [Lrp2], Gene ID: 4036, NCBI: NP_004516.2, UniProt: P98164 |
Catalog # | MBS9604407 |
Price | $240, $280 |
Order / More Info | Lrp2/Megalin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |