Phospho-INSR (Y1185) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-INSR (Y1185) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: bovine, mouse, rat, Xenopus, Drosophila) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | n/a |
| Applications | Dot Blot (DB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This INSR Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. |
| Immunogen | n/a |
| Other Names | [Insulin receptor; IR; CD220; Insulin receptor subunit alpha; Insulin receptor subunit beta; INSR] |
| Gene, Accession # | [INSR], Gene ID: 3643, NCBI: P06213, UniProt: Q9PVZ4 |
| Catalog # | MBS9204291 |
| Price | $165, $370 |
| Order / More Info | Phospho-INSR (Y1185) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Nakamaru, K., et al., Biochem. Biophys. Res. Commun. 328(2):449-454 (2005). Diaz, E., et al., Clin. Biochem. 38(3):243-247 (2005). McGettrick, A.J., et al., J. Biol. Chem. 280(8):6441-6446 (2005). Schmitt, T.L., et al., J. Biol. Chem. 280(5):3795-3801 (2005). Denley, A., et al., Mol. Endocrinol. 18(10):2502-2512 (2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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