Phospho-EGFR-Y998 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-EGFR-Y998
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formataffinity purified
Size0.05 mL, 0.1 mL, 0.2 mL
Concentration1mg/ml
ApplicationsWestern Blot (WB)
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DescriptionThe epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation (1,2). Phosphorylation of EGF receptor (EGFR) at Tyr845 in the kinase domain is implicated in stabilizing the activation loop, maintaining the active state enzyme, and providing a binding surface for substrate proteins (3,4). c-Src is involved in phosphorylation of EGFR at Tyr845 (5). The SH2 domain of PLCgamma binds at phospho-Tyr992, resulting in activation of PLCgamma-mediated downstream signaling (6). Phosphorylation of EGFR at Tyr1045 creates a major docking site for t
ImmunogenImmunogen: A phospho specific peptide corresponding to residues surrounding Y998 of human EGFR
Other Names[Phospho-EGFR-Y998: ERBB; HER1; mENA; ERBB1; PIG61; EGFR], [EGFR; EGFR; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; ERBB; ERBB1; HER1]
Gene, Accession #[EGFR], Gene ID: 1956, NCBI: P00533.2, UniProt: P00533
Catalog #MBS125120
Price$235, $350, $525
Order / More InfoPhospho-EGFR-Y998 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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