Phospho-ERK3-S189 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-ERK3-S189
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionErk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region (1). However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, possessing instead an SEG motif (1, 2). Phosphorylation at Ser189 in the SEG motif has been reported (2, 3). With limited information about its upstream kinases and downstream substrates, the significance of this phosphorylation remains to be elucidated (3, 4). Erk3 is an inherently unstable protein, rapidly degraded through amino-terminal ubiquitination and proteasome degradation (3, 5). A site-specific cleavage, depending on a short stretch of acidic residues of Erk3, might regulate its t
ImmunogenImmunogen: A phospho specific peptide corresponding to residues surrounding S189 of human ERK3 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[DKFZp686F03189; ERK3; HsT17250; PRKM6; p97MAPK; MAPK6]
Gene, Accession #[ERK3-S189], Gene ID: 5597, NCBI: NP_002739.1, UniProt: Q16659
Catalog #MBS8527437
Price$310
Order / More InfoPhospho-ERK3-S189 Antibody from MYBIOSOURCE INC.
Product Specific References1. Boulton, T. G. et al. (1991) Cell 65, 663-675. 2. Cheng, M. et al. (1996) J. Biol. Chem. 271, 12057-12062. 3. Coulombe, P. et al. (2003) Mol. Cell. Biol. 23, 4542-4558. 4. Julien, C. et al. (2003) J. Biol. Chem. 278, 42615-42624. 5. Coulombe, P. et al. (2004) Mol. Cell. Biol. 24, 6140-6150. 6. Bind, E. et al. (2004) Mol. Biol. Cell 15, 4457-4466.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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