GSK-3beta (Paired Ser9), Non-phospho Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | GSK-3beta (Paired Ser9), Non-phospho |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | Size: 100 ug/200 ul |
| Applications | ELISA, Western Blot, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody recognizes GSK-3beta (Paired Ser9) without phosphorylated site at Serine 9. It does not cross-react with phosphospecific peptides. Glycogen Synthase Kinase-3beta (GSK-3beta) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. Growth factor (such as Insulin) binds to its receptor, recruits PKB/AKT kinase to phsphorylate GSK-3beta on Serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. In contrast, the phosphorylation of tyrosine 216 in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3beta is also involved in Wnt signaling pathway where it forms a compl |
| Immunogen | Antigen Preparation: A synthetic peptide surrounding to the epitope -TTSFA- without phosphorylation of human GSK3-beta protein. This sequence is identical among human, mouse, rat, bovine, dog and chicken species |
| Other Names | [Rabbit -GSK3b (Paired S9); Glycogen synthase kinase 3 beta (GSK3-b)], [GSK3B; GSK3B; GSK3B] |
| Gene, Accession # | [GSK3b (Paired S9)], Gene ID: 2932, NCBI: NP_002084.2, UniProt: P49841 |
| Catalog # | MBS462053 |
| Price | $265 |
| Order / More Info | GSK-3beta (Paired Ser9), Non-phospho Antibody from MYBIOSOURCE INC. |
| Product Specific References | Alan P. Kozikowski, et al. Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha- Synuclein Protein Expression in a Cellular Model of Parkinson's Disease. ChemMedChem, 2006, 1 (2), 256-266. |
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MYBIOSOURCE INC.
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