Edit |   |
---|---|
Antigenic Specificity | CD253 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD253 antibody detects endogenous levels of total CD253. Function: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.Subunit Structure: Homotrimer (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10A mononers (PubMed:26457518). One TNFSF10 homotrimer interacts with three TNFSF10B mononers (PubMed:10549288).Post-translational Modifications: Tyrosine phosphorylated by PKDCC/VLK.Similarity: Belongs to the tumor necrosis |
Immunogen | Immunogen: A synthesized peptide derived from human CD253 Subcellular Location: Membrane. Tissue Specificity: Widespread; most predominant in spleen, lung and prostate. Predicted Cross Reactivity: Horse, Dog Similarity: Horse (100%), Dog (90%) |
Other Names | [Apo 2 ligand; APO 2L; Apo-2 ligand; Apo-2L; APO2L; CD253; CD253 antigen; Chemokine tumor necrosis factor ligand superfamily member 10; Protein TRAIL; TL2; TNF Related Apoptosis Inducing Ligand; TNF related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNF10_HUMAN; TNFSF10; TRAIL; Tumor necrosis factor (ligand) family member 10; Tumor Necrosis Factor (ligand) Superfamily Member 10; Tumor necrosis factor apoptosis inducing ligand splice variant delta; Tumor necrosis factor ligand superfamily member 10] |
Gene, Accession # | [CD253], Gene ID: 8743, NCBI: NP_001177871.1, UniProt: P50591 |
Catalog # | MBS9601454 |
Price | $240, $280 |
Order / More Info | CD253 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |