PERK Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | PERK |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: PERK antibody detects endogenous levels of total PERK. Description: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis.Function: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of |
| Immunogen | Immunogen: A synthesized peptide derived from human PERK Subcellular Location: Endoplasmic Reticulum Membrane. Tissue Specificity: Ubiquitous. A high level expression is seen in secretory tissues. |
| Other Names | [DKFZp781H1925; E2AK3_HUMAN; EC 2.7.11.1; Eif2ak3; Eukaryotic translation initiation factor 2 alpha kinase 3; Eukaryotic translation initiation factor 2-alpha kinase 3; Heme regulated EIF2 alpha kinase; HRI; HsPEK; Pancreatic eIF2 alpha kinase; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; PRKR-like endoplasmic reticulum kinase; WRS] |
| Gene, Accession # | [PERK], Gene ID: 9451, NCBI: NP_004827.4, UniProt: Q9NZJ5 |
| Catalog # | MBS9601476 |
| Price | $240, $280 |
| Order / More Info | PERK Antibody from MYBIOSOURCE INC. |
| Product Specific References | Liu Y, Shen HJ, Wang XQ, Liu HQ, Zheng LY, Luo JD; Journal: J Cell Biochem. EndophilinA2 protects against angiotensin II-induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes. Yang X, He J, Li B, Zhang J, He K, Duan X, Huang R, Xiang G; Journal: J Nanosci Nanotechnol. SWNHs (Single-Wall Carbon Nanohorns) Supervises Endoplasmic Reticulum (ER) Stress in Hepatocellular Carcinoma. Lu HY, Chen XQ, Tang W, Wang QX, Zhang J; Journal: Mol Med Rep. GRP78 silencing enhances hyperoxia-induced alveolar epithelial cell apoptosis via CHOP pathway. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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