Phospho-Chk1 (Ser280) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Chk1 (Ser280) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-Chk1 (Ser280) antibody detects endogenous levels of Chk1 only when phosphorylated at Serine 280. Description: DNA damage induced protein phosphorylation; regulation of mitotic centrosome separation; regulation of S phase; peptidyl-threonine phosphorylation; DNA repair; chromatin-mediated maintenance of transcription; negative regulation of mitosis.Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrit |
| Immunogen | Immunogen: A synthesized peptide derived from human Chk1 around the phosphorylation site of Serine 280 Subcellular Location: Cytoskeleton; Nucleus Tissue Specificity: Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Rabbit, Dog Similarity: Pig (100%), Bovine (82%), Horse (91%), Sheep (82%), Rabbit (91%), Dog (100%) |
| Other Names | [C85740; Cell cycle checkpoint kinase; Checkpoint, S. pombe, homolog of, 1; Checkpoint kinase 1; Checkpoint kinase 1 homolog (S. pombe); CHEK 1; Chek1; Chk 1; Chk1; CHK1 checkpoint homolog (S. pombe); CHK1_HUMAN; EC 2.7.11.1; rad27; Serine/threonine protein kinase Chk1; Serine/threonine-protein kinase CHK1; STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)] |
| Gene, Accession # | [CHK1], Gene ID: 1111, NCBI: NP_001107593.1, UniProt: O14757 |
| Catalog # | MBS9600627 |
| Price | $240, $280 |
| Order / More Info | Phospho-Chk1 (Ser280) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Jiang X, Wang J, Xing L, Shen H, Lian W, Yi L, Zhang D, Yang H, Liu J, Zhang X; Journal: Arch Toxicol. Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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