Phospho-CHK1 (S280) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-CHK1 (S280) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.465 |
| Applications | ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This CHK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S280 of human CHK1. Checkpoint pathways control the order and timing of cell cycle transitions and ensure that critical events, such as DNA replication and chromosome segregation, are completed with high fidelity. The S. pombe Chk1 gene encodes a protein kinase that is required for the DNA damage checkpoint. Antibodies against CHK1 recognized a 54-kD protein on immunoblots of mammalian cell extracts. However,CHK1 is modified in response to DNA damage. In vitro, CHK1 directly phosphorylated a regulator of CDC2 tyrosine phosphorylation, CDC25C. In response to DNA damage, CHK1 phosphorylates and |
| Immunogen | n/a |
| Other Names | [Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1; CHEK1; CHK1] |
| Gene, Accession # | [CHEK1], Gene ID: 1111, NCBI: NP_001107593.1, UniProt: O14757 |
| Catalog # | MBS9209803 |
| Price | $165, $370 |
| Order / More Info | Phospho-CHK1 (S280) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Kramer, A., et al., Nat. Cell Biol. 6(9):884-891 (2004). Xu, X., et al., J. Biol. Chem. 279(33):34091-34094 (2004). Ng, C.P., et al., J. Biol. Chem. 279(10):8808-8819 (2004). Chen, M.S., et al., Mol. Cell. Biol. 23(21):7488-7497 (2003). Groth, A., et al., EMBO J. 22(7):1676-1687 (2003). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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