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Antigenic Specificity | MAG |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Myelin-associated glycoprotein(MAG) detection. Tested with WB in Human. Background: MAG (Myelin-associated glycoprotein), also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is thought to be involved in the process of myelination. The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MAG (589-626aa EPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK), different from the related mouse sequence by one amino acid, and identical to the related rat sequence. Ig Type: Rabbit IgG |
Other Names | [Myelin-associated glycoprotein; GMA; MAG; MAG_HUMAN; Myelin associated glycoprotein; Myelin-associated glycoprotein; S MAG; Siglec 4a; Siglec-4a; SIGLEC4A; myelin associated glycoprotein], [MAG; MAG; GMA; S-MAG; SPG75; SIGLEC4A; SIGLEC-4A; GMA] |
Gene, Accession # | [MAG], Gene ID: 4099, NCBI: NP_001186145.1, UniProt: P20916 |
Catalog # | MBS178031 |
Price | $280 |
Order / More Info | MAG Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Atwal, J. K., Pinkston-Gosse, J., Syken, J., Stawicki, S., Wu, J., Shatz, C., Tessier-Lavigne, M. PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science 322: 967-970, 2008. 2. Barton, D. E., Arquint, M., Roder, J., Dunn, R., Francke, U. The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice. Genomics 1: 107-112, 1987. 3. Liu, B. P., Fournier, A., GrandPre, T., Strittmatter, S. M. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297: 1190-1193, 2002. |