Phospho-RPA2 (T21) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-RPA2 (T21)
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Formataffinity purified
Size0.03 mg, 0.1 mg, 0.1 mg
ApplicationsImmunoprecipitation (IP), Western Blot (WB)
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DescriptionAs part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response
ImmunogenImmunogen: A synthesized peptide derived from human Phospho-RPA2 (T21) Subcellular Localization: Nucleus. Nucleus, PML body. Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Other Names[Replication protein A 32 kDa subunit; RP-A p32; Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34; RPA2; REPA2; RPA32; RPA34]
Gene, Accession #[RPA2], Gene ID: 6118, NCBI: NP_001273005.1, UniProt: P15927
Catalog #MBS1750271
Price$160, $340, $340
Order / More InfoPhospho-RPA2 (T21) Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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