NKCC2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NKCC2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peroxidase (HRP) conjugate |
| Size | 0.1 mg |
| Concentration | 1mg/mL |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects ~160kDa Scientific Background: NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell (1, 2). Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide (1). |
| Immunogen | Immunogen: Produced against a synthetic peptide mapping to a segment (amino acids 33-55) of the N-terminal tail of rat NKCC2 (antibody desgination L224). Research Area(s): Cancer, Neuroscience, Pumps/Transporters, Ion Pumps/Transporters. Cellular Localization: Membrane |
| Other Names | [SLCl2A1, sodium potassium chloride cotransporter 2, sodium-potassium-chloride cotransporter isoform 2, BSCl, MBSCl, Na-K-2CI cotransporter, NKCC2A variant A, RBSC,], [Slc12a1; Slc12a1; BSC1; Nkcc2; rCG_26347] |
| Gene, Accession # | Gene ID: 25065, NCBI: NP_062007, UniProt: Q5PQV1 |
| Catalog # | MBS805913 |
| Price | $435 |
| Order / More Info | NKCC2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1.Caceres P.S., Ares G.R., and Ortiz P.A. (2009) J Biol Chem. 284(37): 24965-24971. 2.Xue H., et al. (2009) Neurogastroentrol Motil. 21(10): 1068-1089. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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