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Antigenic Specificity | Amyloid beta A4 (Phospho-Thr743/668) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of Amyloid b A4 only when phosphorylated at threonine 743/668. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Ming-Sum Lee J. Cell Biol., |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid b A4. |
Other Names | [Amyloid b A4 (Phospho-Thr743/668); A4; AD1; APP; APPI; Beta-amyloid protein 42] |
Gene, Accession # | Gene ID: 351, NCBI: NP_000475.1, UniProt: P05067 |
Catalog # | MBS9403557 |
Price | $200, $255 |
Order / More Info | Amyloid beta A4 (Phospho-Thr743/668) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |