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Antigenic Specificity | Synaptopodin |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Synaptopodin(SYNPO) detection. Tested with WB in Human;Mouse. Background: Synaptopodin is also known as SYNPO. The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are thought to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important f |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Synaptopodin(629-658aa EKPKVTPNPDLLDLVQTADEKRRQRDQGEV), different from the related mouse sequence by one amino acid, and identical to the related rat sequence. Ig Type: Rabbit IgG |
Other Names | [Synaptopodin; KIAA1029; Synaptopodin; SYNPO; SYNPO_HUMAN; synaptopodin], [SYNPO; SYNPO; KIAA1029] |
Gene, Accession # | Gene ID: 11346, NCBI: NP_001103444.1, UniProt: Q8N3V7 |
Catalog # | MBS178136 |
Price | $280 |
Order / More Info | Synaptopodin Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Cooney; Hurlburt, JL; Selig, DK; Harris, KM; Fiala, JC (2002). Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane. The Journal of neuroscience : the official journal of the Society for Neuroscience 22 (6): 2215-24. 2. Deller; Merten, T; Roth, SU; Mundel, P; Frotscher, M (2000). Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. The Journal of Comparative Neurology 418 (2): 164-81 3. Gray (1959). Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex. Nature 183 (4675): 1592-3. |