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Antigenic Specificity | SFPQ |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich s |
Immunogen | Immunogen: Recombinant Human Splicing factor, proline- and glutamine-rich protein (499-598AA) |
Other Names | [Splicing factor; proline- and glutamine-rich; 100 kDa DNA-pairing protein; hPOMp100; DNA-binding p52/p100 complex; 100 kDa subunit; Polypyrimidine tract-binding protein-associated-splicing factor; PSF; PTB-associated-splicing factor; SFPQ; PSF] |
Gene, Accession # | [SFPQ], Gene ID: 6421, NCBI: NP_005057.1, UniProt: P23246 |
Catalog # | MBS7103841 |
Price | $160, $235 |
Order / More Info | SFPQ Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |