PKM2 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPKM2
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionPyruvate kinase, a glycolytic enzyme, catalyses the conversion of phosphoenolpyruvate to pyruvate. In mammals, the M1 isoform (PKM1) is expressed in most adult tissues (1). The M2 isoform (PKM2), an alternatively-spliced variant of M1, is expressed during embryonic development (1). Studies found that cancer cells exclusively express PKM2 (1-3). PKM2 is shown to be essential for aerobic glycolysis in tumors (Warburg effect) (1). When the M2 isoform is switched to the M1 isoform, aerobic glycolysis is reduced and oxidative phosphorylation is increased in cancer cells (1). These cells also show decreased tumorigenicity in mouse xenografts (1). Recent studies show that the oncogenic forms of FGFR1 directly phosphorylate Tyr105 of PKM2 and there
ImmunogenImmunogen: Recombinant protein of human PKM2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[PKM2; TCB; PK3; PKM2 pyruvate kinase; muscle; CTHBP; PK2]
Gene, Accession #[PKM2], Gene ID: 5315, NCBI: NP_001193725.1, UniProt: P14618
Catalog #MBS8502760
Price$310
Order / More InfoPKM2 Antibody from MYBIOSOURCE INC.
Product Specific References1. Christofk, H.R. et al. (2008) Nature 452, 230-3. 2. Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8. 3. Dombrauckas, J.D. et al. (2005) Biochemistry 44, 9417-29. 4. Hitosugi, T. et al. (2009) Sci Signal 2, ra73. 5. Hitosugi, T. et al. (2009) Sci Signal 2, ra73.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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