phospho-JNK1 (T183/Y185) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-phospho-JNK1 (T183/Y185) antibody, protein, ELISA kits.
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| Antigenic Specificity | phospho-JNK1 (T183/Y185) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat, human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse, rat, and human phospho-JNK1. The mitogen-activated protein kinases (MAPK) consist of several subgroups, including the ERK, JNK, and p38 kinases. The members of this MAPK family are regulated by many different extracellular cues ranging from cytokines, growth factors, and neuropeptides (1). These stimuli activate cell surface receptors to stresses such as cold, heat, osmolarity changes and irradiation. The pathways regulated by the MAPKs control a broad array of cellular responses ranging from survival, cell proliferation, and apoptosis (1,2). The MAPKs family is also characterized by their requirement for dual phosphorylation at a conserved threonine and tyrosine residue for enzymatic activation and both must be phosphor |
| Immunogen | Immunogen: Synthetic peptide mapping to an internal domain containing phosphorylated T183/Y185 of human JNK1. |
| Other Names | n/a |
| Gene, Accession # | NCBI: ABK42246.1 |
| Catalog # | MBS440059 |
| Price | $285 |
| Order / More Info | phospho-JNK1 (T183/Y185) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1.)C. Katagiri, K. Negishi, T. Hibino. 2006. c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis. Journal of Dermatological Science, Volume 43, Issue 3, Pages 171-179.1. Fanger GR. 1999. Regulation of the MAKP family members: role of the subcellular localization and architectural organization. Histol Histopathol 14(3):887-894. 2. Kyriakis JM. 1999. Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signaling modules to extracellular stimuli and biological responses. Biochem Soc Symp 64:29-48.3. Prowse CN, Lew J. 2001. Mechanism of activation of ERK2 by dual phosphorylation. J Biol Chem 276(1):99-103.4. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369(6476):156-160. 5. Cha H, Shapiro P. 2001. Tyrosine-phosphorylated extracellular signal- -regulated kinase associates with Golgi complex during G2/M phase of the cell cycle: evidence for regulation of Golgi structure. J Cell Biol 153(7):1355-1367.6. Chan ED, Winston BW, Jarpe MB, Wynes MW, Riches DW. 1997. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNF alpha. Proc Natl Acad Sci USA 94(24):13169-13174.7. Nishida E, Gotoh Y. 1993. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18:128-131. |
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