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Antigenic Specificity | ZCCHC8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone-and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. |
Immunogen | Immunogen: Recombinant protein of human ZCCHC8 (NP 060082.2). |
Other Names | [zinc finger CCHC domain-containing protein 8 isoform 1; Zinc finger CCHC domain-containing protein 8; zinc finger CCHC domain-containing protein 8; zinc finger CCHC-type containing 8] |
Gene, Accession # | [ZCCHC8], Gene ID: 55596, NCBI: NP_060082.2, UniProt: Q6NZY4 |
Catalog # | MBS8574250 |
Price | $280 |
Order / More Info | ZCCHC8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |