Phospho-Akt (Ser473) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPhospho-Akt (Ser473)
Clone[3B3]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG
FormatProtein A purified
Size0.02 mL, 0.06 mL, 0.12 mL
Concentration1mg/mL
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC) Paraffin
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DescriptionThe serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
ImmunogenImmunogen: Synthetic Peptide of Phospho-Akt (Ser473) Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 Conjugation: Unconjugated
Other Names[AKT1]
Gene, Accession #[Akt], Gene ID: 207, NCBI: NP_001014431.1, UniProt: P31749
Catalog #MBS2548821
Price$110, $150, $225
Order / More InfoPhospho-Akt (Ser473) Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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