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Antigenic Specificity | Phospho- STAT3 (pTyr 705) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse, dog, bovine, chicken |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes STAT3 (pY705) with a phosphorylated sites of Tyr705. It does not cross-react with non-phosphospecific peptide. STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. The phosphorylation of STAT3 induces STAT dimerization, nuclear translocation and DNA binding. Stat3 is constitutively activated in a number of human tumors. Stat3- activated transcription seems to be regulated by serine phosphorylation at Ser727 and tyrosine phosphorylation at Tyr705. |
Immunogen | Antigen Preparation: A synthetic peptide surrounding to the epitope -APYLK-- with phosphorylation sites at Tyr705 of STAT3 protein from human, mouse, rat, chicken dog and bovine origins. |
Other Names | [Rabbit Phospho-STAT3 (pY705); Signal transducer and activator of transcription 3 (STAT3)], [STAT3; STAT3; APRF; HIES; FLJ20882; MGC16063; APRF] |
Gene, Accession # | [STAT3 (pY705)], Gene ID: 6774, NCBI: NP_644805.1, UniProt: P40763 |
Catalog # | MBS462114 |
Price | $285 |
Order / More Info | Phospho- STAT3 (pTyr 705) Antibody from MYBIOSOURCE INC. |
Product Specific References | Ritsuko Matsuo et al. A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody. Journal of Immunological Methods. Volume 247, Issues 1-2, 1 January 2001, Pages 141-151 |