Cleaved PARP Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCleaved PARP
Host SpeciesRabbit
Reactive Specieshuman
Formataffinity purified
Size0.03 mg, 0.1 mg, 0.1 mg
ApplicationsFlow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB)
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DescriptionInvolved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. R
ImmunogenImmunogen: A synthesized peptide derived from human Cleaved PARP. Subcellular Localization: Nucleus. Nucleus, nucleolus. Localizes at sites of DNA damage.
Other Names[Poly [ADP-ribose] polymerase 1; PARP-1;; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; PARP1; ADPRT; PPOL], [PARP1; PARP1; PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; ADPRT; PPOL; PARP-1; ARTD1; ADPRT 1]
Gene, Accession #[PARP1], Gene ID: 142, NCBI: NP_001609.2, UniProt: P09874
Catalog #MBS179126
Price$160, $340, $340
Order / More InfoCleaved PARP Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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